Butea superba
 

Cortés-González, J. R., J. A. Arratia-Maqueo , L. S. Gómez-Guerra and A. R. Holmberg. 2010.  The use of Butea superba (Roxb.) compared to sildenafil for treating erectile dysfunction. BJU Int. 105, 2: 225-228.

OBJECTIVE: To evaluate the effect of an extract of Butea superba (Roxb.) (BS) compared to sildenafil for treating erectile dysfunction (ED). PATIENTS AND METHODS: An open label study was carried out among 32 men with organic ED to evaluate the response on the International Index of Erectile Function 5 (IIEF-5) to BS, a 'natural health' product (100 mg), compared to 50 mg of sildenafil (a phosphodiesterase-5 inhibitor). After a 1-week wash-out, responders to BS received either 100 mg starch or 100 mg of another batch of BS (double-blind). RESULTS: Of the patients in the BS group, 27 (84%) responded positively, compared with 26 (81%) in the sildenafil group. When assessing the score alone, 12 (38%) had a better score after taking BS, compared to seven (22%) after sildenafil, and eight (25%) had the same score. The results were surprising and could not be repeated in the double-blind part of the study, where no effect of BS was recorded. CONCLUSIONS: A 'natural' health product containing BS was more effective than sildenafil in the first part of the study, but in the second, using another batch of BS, the positive result could not be repeated and no effect was recorded. The conclusion is that the first preparation of BS was most likely blended with a phosphodiesterase-5 inhibitor, later confirmed by the supplier of BS (a natural health products company) after their own analysis.

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Cherdshewasart, W. and N. Nimsakul. 2003. Clinical trial of Butea superba, an alternative herbal treatment for erectile dysfunction. Asian J Androl. 5: 243-246.

Abstract

Aim: To study the effect of Butea superba on erectile dysfunction (ED) in Thai males.

Methods: A 3-month randomized double-blind clinical trial was carried out in volunteers with ED, aged 30 years ~ 70 years, to evaluate the therapeutic effect of the crude preparation of Butea superba tubers on ED.

Results: There was a significant upgrading in 4 of the 5 descriptive evaluations of the IIEF-5 questionnaire. Estimation of the sexual record indicated that; 82.4 % of the patients exhibited noticeable improvement. Haematology and blood chemistry analysis revealed no apparent change.

Conclusion: The plant preparation appears to improve the erectile function in ED patients without apparent toxicity.

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Cherdshewasarta, W., S. Sriwatcharakulb and S. Malaivijitnond. 2008. Variance of estrogenic activity of the phytoestrogen-rich plant. Maturitas 61: 350–357.

Abstract

Objective: To evaluate the influences of seasonal changes and plant cultivars on estrogenic activity of the phytoestrogen-rich plant, Pueraria mirifica.

Methods: Three cultivars of P. mirifica; PM-I, PM-II and PM-V, were grown in the same field trial for 3 years and random tubers collected during the summer, rainy season and winter seasons. Female Wistar rats were ovariectomized, kept for 14 days, randomly segregated into groups and treated with one of DW, 200g/100g BW 17-estradiol (E2) or tuberous powder of PM-I, PM-II and PM-V at dosages of 100, or 1000 mg/kgBW for the next 14 days. For the last 7days of post-treatment period, rats receivedonlyDW. The vaginal cornificationwas recorded during the treatment and post-treatment period. The uterine tissues of the treated rats at the treatment and post-treatment periodswere analyzed for uterine gland number and for the surface area of the myometrium, endometrium and lumen. In addition, ethanol tuberous extracts of PM-I, PM-II and PM-V was submitted to DPPH analysis.

Results: Vaginal cornification exhibited a dose-dependent response with plant samples collected during the winter and summer being more active than those collected in the rainy season. All plant samples-induced uterotrophic effects in the analysis at the treatment and post-treatment periods in a dose-dependent manner. The P. mirifica treated rats exhibited increasing uterine gland numbers and thickness of the endometrium and myometrium but a decreasing size of lumen, in comparison to the negative control. The results were more prominent in PM-I than other plants and also in plant samples collected during the winter and summer seasons than in the rainy season. DPPH assay of the ethanol tuberous extracts revealed variance in antioxidant activity.

Conclusion: The results of uterotrophic and vaginal cornification assays reveal that P. mirifica exhibits a dose-dependent estrogenic activity under the influence of both seasonal changes and plant cultivars, which is confirmed by DPPH assay.